Season 5 Episode 18 – Here Kitty
A nursing home worker, Morgan, fakes an illness to get House to examine a cat which can predict the death of elderly patients. House doesn't believe it... until Morgan becomes ill for real.
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Season 5 Episode 17 – The Social Contract
A book editor (Jay Karnes) suddenly begins insulting coworkers at a dinner party then falls ill. His loss of inhibition continues at the hospital, and this inability to lie affects his relationships with people close to him. Meanwhile, House suspects that Wilson and Taub are hiding something from him.
Season 5 Episode 16 – The Softer Side
A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.
Season 5 Episode 15 – Unfaithful
A priest who runs a homeless shelter is admitted to the ER after seeing a bleeding Jesus hovering at his doorstep. House takes the case to distract the team while he confronts Foreman and Thirteen about their relationship, but it causes House to grapple with his past and his beliefs.
Season 5 Episode 14 – The Greater Good
A former cancer researcher collapses in the middle of a cooking class, and the team are forced to reevaluate their own lives when they learn she gave up a promising career to seek personal happiness. Meanwhile, Thirteen suffers adverse reactions from the clinical trials, and Cuddy gives House a dose of his own medicine.
Season 5 Episode 13 – Big Baby
The team take on the case of a Special Education teacher who spits up blood and collapses in the middle of class. Meanwhile, Cameron finds herself taking on some of Cuddy's duties, including dealing with House, and Foreman has to make a decision concerning Thirteen's participation in the clinic trials.
Season 5 Episode 12 – Painless
At Cameron's urging, the team takes the case of a suicidal man who suffers from excruciating chronic pain---pain that mirrors House's. Meanwhile, Cuddy discovers that caring for her newly adopted baby leaves her little time to run the hospital; and Foreman and Thirteen continue to explore their complicated relationship as they work together on their Huntington's disease drug trial.
Season 5 Episode 11 – Joy to the World
A troubled teen collapses during her high-school Christmas program; Foreman and Thirteen learn more about each other as they work together on the Huntington's disease drug trial; House gives and receives holiday gifts, leading to team speculation; and Cuddy receives a gift as well.
Season 5 Episode 10 – Let Them Eat Cake
A fitness guru known for her "natural" lifestyle collapses while shooting an infomercial. Meanwhile, Thirteen participates in a clinical drug trial for Huntington's disease led by Foreman; Kutner operates an online medical-advice clinic under House's name; and Cuddy moves into House's office while hers is being repaired, much to House's dismay.
Season 5 Episode 9 – Last Resort
A gun-wielding clinic patient (Zeljko Ivanek) takes House, Thirteen and several other patients hostage in Cuddy's waiting room and demands that House diagnose and treat him. The hostage taker also demands that House use other patients as guinea pigs for any medication he is going to receive. Thirteen volunteers for the treatment.