A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son’s medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.
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When a controversial African politician falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House's prying exacerbates the problem.
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House returns to Princeton Plainsboro, announcing he will make big changes in his life. Meanwhile, House's team can't diagnose a new patient who's obsessed with posting each and every one of his symptoms over the Internet.
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House engages in a battle of wits and wills against the attending physician in charge of his detox program. When he starts to lose, House resorts to blackmail to gain the upper hand.
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House takes on a case of a patient with two different personalities as a result of having the left and right part of the brain operating independently.
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While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a performance.
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A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House's insomnia proves a curse... and a blessing.
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Cameron and Chase are going on vacation when they meet an enviromentalist who collapses in the middle of a protest. They postpone their vacation and ask House to take on the case.
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The team deals with an older woman who has been tending to her dying husband but is stricken down with an unknown disease that threatens to kill her before her husband.
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House is injured in a motorcycle accident in New York and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what's wrong with him, Wilson tries to find out why House was in New York.
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