Season 5 Episode 24 – Both Sides Now
House takes on a case of a patient with two different personalities as a result of having the left and right part of the brain operating independently.
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Season 5 Episode 23 – Under My Skin
While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a performance.
Season 5 Episode 22 – House Divided
A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House's insomnia proves a curse... and a blessing.
Season 5 Episode 21 – Saviors
Cameron and Chase are going on vacation when they meet an enviromentalist who collapses in the middle of a protest. They postpone their vacation and ask House to take on the case.
Season 5 Episode 20 – Simple Explanation
The team deals with an older woman who has been tending to her dying husband but is stricken down with an unknown disease that threatens to kill her before her husband.
Season 5 Episode 19 – Locked In
House is injured in a motorcycle accident in New York and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what's wrong with him, Wilson tries to find out why House was in New York.
Season 5 Episode 18 – Here Kitty
A nursing home worker, Morgan, fakes an illness to get House to examine a cat which can predict the death of elderly patients. House doesn't believe it... until Morgan becomes ill for real.
Season 5 Episode 17 – The Social Contract
A book editor (Jay Karnes) suddenly begins insulting coworkers at a dinner party then falls ill. His loss of inhibition continues at the hospital, and this inability to lie affects his relationships with people close to him. Meanwhile, House suspects that Wilson and Taub are hiding something from him.
Season 5 Episode 16 – The Softer Side
A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.
Season 5 Episode 15 – Unfaithful
A priest who runs a homeless shelter is admitted to the ER after seeing a bleeding Jesus hovering at his doorstep. House takes the case to distract the team while he confronts Foreman and Thirteen about their relationship, but it causes House to grapple with his past and his beliefs.